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Article

Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer

5 Apr 2023

Abstract excerpt

Predicting and treating recurrence in intermediate-risk prostate cancer patients remains a challenge despite having identified genomic instability [1] and hypoxia [2, 3] as risk factors. This underlies challenges in assigning the functional impact of these risk factors to mechanisms promoting prostate cancer progression. Here we show chronic hypoxia (CH), as observed in prostate tumours [4], leads to the adoption...

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Share to Cancer, Hypoxia, and Metabolism
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PMID: 37020039
DOI: 10.1038/s41388-023-02680-z

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