Article

Interleaved intersectional strategy enables genetic lineage tracing with enhanced specificity

2024-03-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Dual recombinases have been increasingly employed for enhanced precision in genetic targeting. A recent study utilizing an intersectional genetic approach through dual recombinases (Dre + CreER) has revealed that endocardium-derived fibroblasts (EndoFbs) play a pivotal role in cardiac fibrosis after pressure overload. However, this intersectional strategy has limitations, pr...

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Literature Corpus work: c1b9d8b3-91c1-50b3-b3f4-f01c633fc013
DOI: 10.1101/2024.03.06.583635

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