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A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mesenchyme

15 Aug 2018

Abstract excerpt

ABSTRACT In vivo genomic engineering is instrumental for studying developmental biology and regenerative medicine. Development of novel systems with more site-specific recombinases (SSRs) that complement with the commonly used Cre-loxP would be valuable for more precise lineage tracing and genome editing. Here, we introduce a new SSR system via Nigri-nox. By generating tissue-specific Nigri knock-in and its...

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PMID: 30111655
DOI: 10.1242/dev.167775

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