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Article

Simultaneous quantitative assessment of two distinct cell lineages with a nuclear-localized dual genetic reporter.

Journal of molecular and cellular cardiology - 1 Sept 2020

Tang Muxue, Liu Kuo, Jin Hengwei, Li Yan, Zhang Shaohua, Liu Xiuxiu, Han Ximeng, Han Maoying, Zhang Zhenqian, Zhou Bin

Abstract excerpt

Genetic lineage tracing has been widely used for studying in vivo cell fate plasticity during embryogenesis, tissue homeostasis, and disease development. Recent applications with multiple site-specific recombinases have been used in complex and sophisticated genetic fate mapping studies. However, the previous multicolor reporters for dual recombinases had limitations of precise in situ quantification of cell...

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PMID: 32668281
DOI: 10.1016/j.yjmcc.2020.07.002

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