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Article

Polymerase I as a Target for Treating Neurodegenerative Disorders

15 May 2024

Abstract excerpt

Polymerase I (Pol I) is at the epicenter of ribosomal RNA (rRNA) synthesis. Pol I is a target for the treatment of cancer. Given the many cellular commonalities between cancer and neurodegeneration (i.e., different faces of the same coin), it seems rational to consider targeting Pol I or, more generally, rRNA synthesis for the treatment of disorders associated with the death of terminally differentiated neurons....

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PMID: 38791054
DOI: 10.3390/biomedicines12051092

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