Article

Polymerase I as a Target for Treating Neurodegenerative Disorders

2024-04-04

Abstract excerpt

Polymerase I (Pol I) is at the epicenter of ribosomal RNA (rRNA) synthesis. Pol I is a target for treatment of cancer. Given the many cellular commonalities between cancer and neurodegeneration (i.e., different faces of the same coin) it seems rational to consider targeting of Pol I or, more generally, rRNA synthesis for treatment of disorders associated with the death of terminally differentiated neurons. Princip...

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Literature Corpus work: 20b462d6-7bba-5499-83c3-5e4c3eaa4ae3
DOI: 10.20944/preprints202404.0322.v1

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