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Article

The NOTCH4-GATA4-IRG1 axis as a novel target in early-onset colorectal cancer

29 Jun 2022

Abstract excerpt

The early onset of colorectal cancer (CRC) in individuals younger than 50 years is an emerging phenomenon, and obesity is a strong risk factor. Inflammatory mechanisms are mediated by immune cells, with macrophages and their phenotypical changes playing a significant role in CRC. Obesity-related hormones, such as leptin and adiponectin, affect macrophage polarization and cytokine expression. Macrophage...

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PMID: 35941043
DOI: 10.1016/j.cytogfr.2022.06.002

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