Article
Variants of the PPARD gene and their clinicopathological significance in colorectal cancer.
PloS one - 1 Jan 2013
Ticha Ivana, Gnosa Sebastian, Lindblom Annika, Liu Tao, Sun Xiao-Feng
Abstract excerpt
BACKGROUND: Peroxisome proliferator-activated receptor delta (PPARD) is nuclear hormone receptor involved in colorectal cancer (CRC) differentiation and progression. The purpose of this study was to determine prevalence and spectrum of variants in the PPARD gene in CRC, and their contribution to clinicopathological endpoints. METHODS AND FINDINGS: Direct sequencing of the PPARD gene was performed in 303 primary...
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