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Article

PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis.

Cell death & disease - 24 Jun 2023

Pan Rulu, Dai Juji, Liang Weicheng, Wang Hongxiao, Ye Lin, Ye Siqi, Lin Ziqi, Huang Shishun, Xiong Yan, Zhang Li, Lu Liting, Wang Ouchen, Shen Xian, Liao Wanqin, Lu Xincheng

Abstract excerpt

Phosphodiesterase 4D interacting protein (PDE4DIP) is a centrosome/Golgi protein associated with cyclic nucleotide phosphodiesterases. PDE4DIP is commonly mutated in human cancers, and its alteration in mice leads to a predisposition to intestinal cancer. However, the biological function of PDE4DIP in human cancer remains obscure. Here, we report for the first time the oncogenic role of PDE4DIP in colorectal...

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Identifiers

PMID: 37355626
DOI: 10.1038/s41419-023-05885-y
PMCID: PMC10290635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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