Article

Identification and functional analysis of circulating extrachromosomal circular DNA in schizophrenia implicate its negative effect on the disorder

2023-08-24

Abstract excerpt

<h4>Background: </h4> Extrachromosomal circular DNA (eccDNA) is a circular DNA molecule derived and free from linear chromosome, its characteristics and potential function in SCZ remain unclear. <h4>Methods: </h4> Here, we explored the presence of circulating eccDNA in the plasma of chronic SCZ and healthy control using Circle-seq. Then the molecular role of SCZ over-represented eccDNAs was investigated by bioinf...

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Literature Corpus work: c15927cd-8651-505f-8de2-71d03a5fae84
DOI: 10.21203/rs.3.rs-3287964/v1

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