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Identification and Characterization of Extrachromosomal Circular DNA in Human Placentas With Fetal Growth Restriction

21 Dec 2021

Abstract excerpt

Many studies have confirmed that extrachromosomal circular DNAs (eccDNAs/ecDNAs) exist in tumor and normal cells independently of the chromosome and are essential for oncogene plasticity and drug resistance. Studies have confirmed that there are many eccDNAs/ecDNAs in maternal plasma derived from the fetus. Fetal growth restriction (FGR) is a pregnancy-related disease associated with high newborn morbidity and...

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PMID: 34992600
DOI: 10.3389/fimmu.2021.780779

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