Article

Molecular Mechanisms of Gain-of-Function Mutations in λ Cro Revealed by Molecular Dynamics Simulations

2025-08-19

Abstract excerpt

Transcription factors regulate gene expression by coordinating complex networks in organisms ranging from bacteriophages to humans. Bacteriophage λ Cro is a 66-residue repressor that binds DNA as a dimer to block transcription. Because of its small size, simple structure, and well-characterized function, Cro has long served as a model system for understanding the structure/function relationship in transcription fa...

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Literature Corpus work: c11ea570-bde1-5b96-a095-76e78e954012
DOI: 10.1101/2025.08.14.670369

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