The DNA binding arm of lambda repressor: critical contacts from a flexible region.

doi:10.1126/science.254.5029.267

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Article

The DNA binding arm of lambda repressor: critical contacts from a flexible region.

Science (New York, N.Y.) - 11 Oct 1991

Clarke N D, Beamer L J, Goldberg H R, Berkower C, Pabo C O

Abstract excerpt

Segments of protein that do not adopt a well-ordered conformation in the absence of DNA can still contribute to site-specific recognition of DNA. The first six residues (NH2-Ser1-Thr2-Lys3-Lys4-Lys5-Pro6-) of phage lambda repressor are flexible but are important for site-specific binding. Low-tem...

Topics

Amino Acid Sequence
Bacteriophage lambda
DNA, Viral
DNA-Binding Proteins
Genetic Variation
Molecular Sequence Data
Nucleic Acid Conformation
Repressor Proteins
Viral Proteins
Viral Regulatory and Accessory Proteins
X-Ray Diffraction

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