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Article

The DNA binding arm of lambda repressor: critical contacts from a flexible region.

Science (New York, N.Y.) - 11 Oct 1991

Clarke N D, Beamer L J, Goldberg H R, Berkower C, Pabo C O

Abstract excerpt

Segments of protein that do not adopt a well-ordered conformation in the absence of DNA can still contribute to site-specific recognition of DNA. The first six residues (NH2-Ser1-Thr2-Lys3-Lys4-Lys5-Pro6-) of phage lambda repressor are flexible but are important for site-specific binding. Low-temperature x-ray crystallography and codondirected saturation mutagenesis were used to study the role of this segment....

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Source

Identifiers

PMID: 1833818
DOI: 10.1126/science.254.5029.267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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