Article

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

2020-07-09

Abstract excerpt

<h4>ABSTRACT</h4> The emergence of SARS-CoV-2 has created an international health crisis. Small animal models mirroring SARS-CoV-2 human disease are essential for medical countermeasure (MCM) development. Mice are refractory to SARS-CoV-2 infection due to low affinity binding to the murine angiotensin-converting enzyme 2 (ACE2) protein. Here we evaluated the pathogenesis of SARS-CoV-2 in male and female mice expr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1103ba9-0bed-50e3-8f59-829acfb8ffd3
DOI: 10.1101/2020.07.09.195230

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory diseaseDOI 10.1101/2020.07.09.195230Read

Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2Semantic proximity Read

Highly susceptible SARS-CoV-2 model in CAG promoter–driven hACE2-transgenic miceSemantic proximity Read

Characterization of low copy number human angiotensin-converting enzyme 2 (hACE2)-transgenic mice as an improved model of SARS-CoV-2 infectionSemantic proximity Read

Development and characterization of a fully humanized ACE2 mouse modelSemantic proximity Read

Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2Semantic proximity Read

Evaluation of K18- <i>hACE2</i> mice as a model of SARS-CoV-2 infectionSemantic proximity Read

Simulation of COVID-19 Symptoms in a Genetically Engineered Mouse ModelSemantic proximity Read

Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic modelSemantic proximity Read

Differential outcomes of infection by wild-type SARS-CoV-2 and the B.1.617.2 and B.1.1.529 variants of concern in K18-hACE2 transgenic miceSemantic proximity Read

Mice Humanized for Major Histocompatibility Complex and Angiotensin-Converting Enzyme 2 with High Permissiveness to SARS-CoV-2 Omicron ReplicationSemantic proximity Read

SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice.Semantic proximity Read

ACE2 mouse models: a toolbox for cardiovascular and pulmonary researchSemantic proximity Read