Article

Characterization of low copy number human angiotensin-converting enzyme 2 (hACE2)-transgenic mice as an improved model of SARS-CoV-2 infection

2023-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Coronaviridae are significant human pathogens, as evidenced by several outbreaks of severe respiratory infections in the past 20 years and culminating with the COVID-19 pandemic. Mouse models of COVID-19 have included transgenic expression of the main SARS coronavirus entry receptor on human cells, human angiotensin-converting enzyme 2 (hACE2). However, the original hACE2-Tg mouse strain overexp...

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Literature Corpus work: f1270677-88e4-5de3-8099-58429e03b383
DOI: 10.1101/2023.08.31.555800

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