Article

Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2

2020-10-10

Abstract excerpt

COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV-2) that uses human angiotensinconverting enzyme 2 (hACE2) as the entry receptor. Here, we successfully developed a SARS-CoV-2 hACE2 transgenic mouse (HFH4-hACE2 in C3B6 mice) infection model. The infected mice generated typical interstitial...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b41f6552-16f1-5efa-bcd3-23fef858a615
DOI: 10.17615/8tnm-fc73

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2DOI 10.17615/8tnm-fc73Read

Highly susceptible SARS-CoV-2 model in CAG promoter–driven hACE2-transgenic miceSemantic proximity Read

Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2Semantic proximity Read

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory diseaseSemantic proximity Read

Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.Semantic proximity Read

Characterization of low copy number human angiotensin-converting enzyme 2 (hACE2)-transgenic mice as an improved model of SARS-CoV-2 infectionSemantic proximity Read

A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infectionSemantic proximity Read

SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice.Semantic proximity Read

COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic miceSemantic proximity Read

Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic modelSemantic proximity Read

An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivoSemantic proximity Read

Mice Humanized for Major Histocompatibility Complex and Angiotensin-Converting Enzyme 2 with High Permissiveness to SARS-CoV-2 Omicron ReplicationSemantic proximity Read

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infectionSemantic proximity Read