Article

Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model

2021-05-04

Abstract excerpt

<h4>Summary</h4> The COVID-19 pandemic is caused by SARS-CoV-2 infection. Human angiotensin-converting enzyme II (hACE2) has been identified as the receptor enabling SARS-CoV-2 host entry. To establish a mouse model for COVID-19, we generated transgenic mouse lines using the (HS4) 2 -pCAG-hACE2-HA-(HS4) 2 transgene cassette, which expresses HA-tagged hACE2 under control of the CAG promoter and is flanked by HS4...

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Literature Corpus work: 235a4798-276a-598a-8232-da21f2487f09
DOI: 10.1101/2021.05.04.441029

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