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Development and characterization of a fully humanized ACE2 mouse model

1 Jul 2025

Abstract excerpt

BACKGROUND: Many humanized angiotensin-converting enzyme 2 (ACE2) mouse models of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection do not replicate human ACE2 protein expression and thus exhibit pathology infrequently observed in humans. To address this limitation, we designed and characterized a fully humanized ACE2 (hACE2) mouse by replacing all exons/introns of the mouse Ace2 locus with...

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PMID: 40597093
DOI: 10.1186/s12915-025-02293-w

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