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Article

SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice.

Journal of virology - 12 Jan 2022

Winkler Emma S, Chen Rita E, Alam Fahmida, Yildiz Soner, Case James Brett, Uccellini Melissa B, Holtzman Michael J, Garcia-Sastre Adolfo, Schotsaert Michael, Diamond Michael S

Abstract excerpt

The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled testing of vaccines and therapeutics and defining aspects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. SARS-CoV-2 disease is severe in K18 transgenic mice (K18-hACE2 Tg) expressing human angiotensin-converting enzyme 2 (hACE2), the SARS-CoV-2 receptor, under an ectopic cytokeratin promoter, with...

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Identifiers

PMID: 34668780
DOI: 10.1128/JVI.01511-21
PMCID: PMC8754206

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