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Article

Highly susceptible SARS-CoV-2 model in CAG promoter–driven hACE2-transgenic mice

31 Aug 2021

Abstract excerpt

COVID-19, caused by SARS-CoV-2, has spread worldwide with dire consequences. To urgently investigate the pathogenicity of COVID-19 and develop vaccines and therapeutics, animal models that are highly susceptible to SARS-CoV-2 infection are needed. In the present study, we established an animal model highly susceptible to SARS-CoV-2 via the intratracheal tract infection in CAG promoter-driven human...

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PMID: 34463644
DOI: 10.1172/jci.insight.152529

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