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Article

LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2018

Nguyen Maria, Krainc Dimitri

Abstract excerpt

Recently identified Parkinson's disease (PD) genes involved in synaptic vesicle endocytosis, such as DNAJC6 (auxilin), have further implicated synaptic dysfunction in PD pathogenesis. However, how synaptic dysfunction contributes to the vulnerability of human dopaminergic neurons has not been previously explored. Here, we demonstrate that commonly mutated, PD-linked leucine-rich repeat kinase 2 (LRRK2) mediates...

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Source

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Identifiers

PMID: 29735704
DOI: 10.1073/pnas.1717590115
PMCID: PMC6003526

Genes

DNAJC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.PMID 29735704Read ↗

Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-linked Parkinson’s diseaseSemantic proximity Read ↗

Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapseSemantic proximity Read ↗

Dysfunction of synaptic endocytic trafficking in Parkinson’s diseaseSemantic proximity Read ↗

LRRK2 regulates AP2M1 phosphorylation cycles to mediate endocytosis and dopaminergic neurodegenerationSemantic proximity Read ↗

Auxilin, clathrin trafficking and Parkinson's diseaseSemantic proximity Read ↗

Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration.Semantic proximity Read ↗

Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain NeuronsSemantic proximity Read ↗

Sequential screening nominates the Parkinson’s disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosisSemantic proximity Read ↗

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosisSemantic proximity Read ↗

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathologySemantic proximity Read ↗

LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights.Semantic proximity Read ↗

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathologySemantic proximity Read ↗

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