Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson’s Disease

1 Jan 2017

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder that exhibits motor and non-motor symptoms, as well as pathological hallmarks, including dopaminergic (DA) neuron death and formation of α-synuclein (α-Syn) Lewy bodies. Cyclin-G-associated kinase (GAK), a PD susceptibility gene identified through genome-wide association studies (GWAS), is a ubiquitous serine/threonine kinase involved in clathrin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion
Share to Parkinson's Disease Mechanisms and Treatments
Share to Retinal Development and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28147270
DOI: 10.1016/j.celrep.2017.01.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson’s DiseasePMID 28147270Read ↗

Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapseSemantic proximity Read ↗

Auxilin, clathrin trafficking and Parkinson's diseaseSemantic proximity Read ↗

Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-linked Parkinson’s diseaseSemantic proximity Read ↗

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathologySemantic proximity Read ↗

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathologySemantic proximity Read ↗

LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.Semantic proximity Read ↗

dAux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to α-synuclein degradationSemantic proximity Read ↗

Functional Screening of Parkinson’s Disease Susceptibility Genes to Identify Novel Modulators of α-Synuclein Neurotoxicity in Caenorhabditis elegansSemantic proximity Read ↗

Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson's Disease.Semantic proximity Read ↗

Dysfunction of synaptic endocytic trafficking in Parkinson’s diseaseSemantic proximity Read ↗

Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in gliaSemantic proximity Read ↗

Behavioral screening defines the molecular Parkinsonism-related subgroups in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.