Article

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology

2022-03-02

Abstract excerpt

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and auxilin, have been implicated in atypical Parkinsonism. SJ1 knock-in (SJ1-KI RQ ) mice carrying a disease-linked mutation display neurological manifestations reminiscent of Parkin...

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Literature Corpus work: b544cc70-eb4d-590e-8a5e-3826d2a711f9
DOI: 10.1101/2022.02.28.482419

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