Article

Pathway Modeling of Genomic and Tissue-Specific Transcriptomic Architecture Identifies Personalized Mechanisms of Atrial Fibrillation Risk

2026-08-31

Abstract excerpt

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major cause of cardioembolic stroke. Although polygenic risk scores (PRS) are well characterized to quantify inherited susceptibility for AF, they provide limited insight into the pathways and tissues underlying genetic risk, which are critical to uncover for individual risk prediction. In this study, we develop a pathway-level multi-om...

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Literature Corpus work: c0fc4801-0874-5f05-bcbf-894c164c5e9b
DOI: 10.64898/2026.08.25.26361369

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