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Article

Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results From a National Biobank.

Circulation research - 17 Jan 2020

Choi Seung Hoan, Jurgens Sean J, Weng Lu-Chen, Pirruccello James P, Roselli Carolina, Chaffin Mark, Lee Christina J-Y, Hall Amelia W, Khera Amit V, Lunetta Kathryn L, Lubitz Steven A, Ellinor Patrick T

Abstract excerpt

RATIONALE: Genome-wide association studies have identified over 100 genetic loci for atrial fibrillation (AF); recent work described an association between loss-of-function (LOF) variants in TTN and early-onset AF. OBJECTIVE: We sought to determine the contribution of rare and common genetic variation to AF risk in the general population. METHODS: The UK Biobank is a population-based study of 500 000 individuals...

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Identifiers

PMID: 31691645
DOI: 10.1161/CIRCRESAHA.119.315686
PMCID: PMC7007701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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