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Article

Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation.

JAMA cardiology - 1 Dec 2025

Zhang Rufan, Kim Min Seo, Yin Wanqing, Liao Shuangqiao, Zhu Xinyu, Yang Xiong, Yu Kang, Sui Yang, Roselli Carolina, Khurshid Shaan, Chen Qiuli, A Yunga, Zhao Hongqiang, Xu Tingfeng, Huang Xiufeng, Pu Jun, Liu Zhaoqi, Natarajan Pradeep, Zhai Guangyao, Ellinor Patrick T, Wang Minxian, Fahed Akl C

Abstract excerpt

Importance: Atrial fibrillation (AF) has a complex genetic architecture involving common, rare, and somatic variants. The association between these components requires further investigation. Objective: To examine the individual and combined contributions of polygenic, monogenic, and somatic genetic variants to AF incidence, and develop an integrated genomic model (IGM-AF) for improved risk prediction. Design,...

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Identifiers

PMID: 41060636
DOI: 10.1001/jamacardio.2025.3664
PMCID: PMC12509083

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