Article
Novel functional atrial fibrillation risk genes and pathways identified from coexpression analyses in human left atria.
Heart rhythm - 1 Sept 2023
Wass Sojin Youn, Offerman Erik J, Sun Han, Hsu Jeffrey, Rennison Julie H, Cantlay Catherine C, McHale Meghan L, Gillinov A Marc, Moravec Christine, Smith Jonathan D, Van Wagoner David R, Barnard John, Chung Mina K
Abstract excerpt
BACKGROUND: Genomewide association studies have associated >100 genetic loci with atrial fibrillation (AF), but establishing causal genes contributing to AF remains challenging. OBJECTIVE: The purpose of this study was to determine candidate novel causal genes and mechanistic pathways associated with AF risk loci by incorporating gene expression and coexpression analyses and to provide a resource for functional...
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