Article
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study.
Cell reports. Medicine - 18 Jan 2022
Wesolowska-Andersen Agata, Brorsson Caroline A, Bizzotto Roberto, Mari Andrea, Tura Andrea, Koivula Robert, Mahajan Anubha, Vinuela Ana, Tajes Juan Fernandez, Sharma Sapna, Haid Mark, Prehn Cornelia, Artati Anna, Hong Mun-Gwan, Musholt Petra B, Kurbasic Azra, De Masi Federico, Tsirigos Kostas, Pedersen Helle Krogh, Gudmundsdottir Valborg, Thomas Cecilia Engel, Banasik Karina, Jennison Chrisopher, Jones Angus, Kennedy Gwen, Bell Jimmy, Thomas Louise, Frost Gary, Thomsen Henrik, Allin Kristine, Hansen Tue Haldor, Vestergaard Henrik, Hansen Torben, Rutters Femke, Elders Petra, t'Hart Leen, Bonnefond Amelie, Canouil Mickaël, Brage Soren, Kokkola Tarja, Heggie Alison, McEvoy Donna, Hattersley Andrew, McDonald Timothy, Teare Harriet, Ridderstrale Martin, Walker Mark, Forgie Ian, Giordano Giuseppe N, Froguel Philippe, Pavo Imre, Ruetten Hartmut, Pedersen Oluf, Dermitzakis Emmanouil, Franks Paul W, Schwenk Jochen M, Adamski Jerzy, Pearson Ewan, McCarthy Mark I, Brunak Søren
Abstract excerpt
The presentation and underlying pathophysiology of type 2 diabetes (T2D) is complex and heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data-driven approaches, but their clinical utility may be limited if categorical representations of complex phenotypes are suboptimal. We apply a soft-clustering (archetype) method to characterize newly diagnosed T2D based on 32 clinical...
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