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Article

TGF‐β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment

17 Apr 2012

Abstract excerpt

Microglia are myeloid-derived cells that colonize the central nervous system (CNS) at early stages of development and constitute up to 20% of the glial populations throughout life. While extensive progress has been recently made in identifying the cellular origin of microglia, the mechanism whereby the cells acquire the unique ramified and quiescent phenotype within the CNS milieu remains unknown. Here, we show...

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PMID: 22511296
DOI: 10.1002/glia.22343

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