Article

Radial glia promote microglial development through integrin α <sub>V</sub> β <sub>8</sub> -TGFβ1 signaling

2023-07-13

Abstract excerpt

<h4>Summary</h4> Microglia diversity emerges from interactions between intrinsic genetic programs and environment-derived signals, but how these processes unfold and interact in the developing brain remains unclear. Here, we show that radial glia-expressed integrin beta 8 (ITGB8) expressed in radial glia progenitors activates microglia-expressed TGFβ1, permitting microglial development. Domain-restricted deletion...

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Identifiers and source

Literature Corpus work: 8b24bfd0-7699-50bb-a794-67ddf74aac48
DOI: 10.1101/2023.07.13.548459

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Radial glia promote microglial development through integrin α <sub>V</sub> β <sub>8</sub> -TGFβ1 signalingDOI 10.1101/2023.07.13.548459Read

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