Article
Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum.
Neurobiology of aging - 1 Jun 2021
Rubinski Anna, Tosun Duygu, Franzmeier Nicolai, Neitzel Julia, Frontzkowski Lukas, Weiner Michael, Ewers Michael
Abstract excerpt
Alzheimer's disease (AD) is associated with reduced temporo-parietal cerebral blood flow (CBF). However, a substantial variability in CBF across the clinical spectrum of AD has been reported, possibly due to differences in primary AD pathologies. Here, we assessed CBF (ASL-MRI), tau (AV1451-PET) and amyloid (AV45/FBB-PET) in 156 subjects across the AD continuum. Using mixed-effect regression analyses, we assessed...
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