Article

Contribution of structural variation to genome structure: TAD fusion discovery and ranking

2018-03-09

Abstract excerpt

The significant contribution of structural variants to function, disease, and evolution is widely reported. However, in many cases, the mechanism by which these variants contribute to the phenotype is not well understood. Recent studies reported structural variants that disrupted the three-dimensional genome structure by fusing two topologically associating domains (TADs), such that enhancers from one TAD interact...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c0cad27d-ddbb-5c19-a0a3-6244e93aa13e
DOI: 10.1101/279356

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Contribution of structural variation to genome structure: TAD fusion discovery and rankingDOI 10.1101/279356Read

A 3D genome atlas of genetic variants and their pathological effectsSemantic proximity Read

Prioritisation of Structural Variant Calls in Cancer GenomesSemantic proximity Read

Three-dimensional reconstruction of protein networks provides insight into human genetic disease.Semantic proximity Read

Leveraging three-dimensional chromatin architecture for effective reconstruction of enhancer-target gene regulatory interactions.Semantic proximity Read

Discovery of A Polymorphic Gene Fusion via Bottom-Up Chimeric RNA PredictionSemantic proximity Read

Evaluating the contribution of genome 3D folding to variation in human height using machine learningSemantic proximity Read

Deep Learning Approach to Genomic Breakage Study from Primary SequenceSemantic proximity Read

Genome Fusion Detection: a novel method to detect fusion genes from SNP-array data.Semantic proximity Read

Breaking TADs: How Alterations of Chromatin Domains Result in Disease.Semantic proximity Read

Statistical model integrating interactions into genotype-phenotype association mapping: an application to reveal 3D-genetic basis underlying AutismSemantic proximity Read

Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational study.Semantic proximity Read

Lessons from the analysis of TAD boundary deletions in normal populationSemantic proximity Read