Article

RIPPLET: Mutation-Only Gene and Pathway Profiling for Precision Oncology

2025-09-19

Abstract excerpt

Clinical implementation of comprehensive genomic profiling, via whole-genome (WGS) or whole-exome sequencing (WES), is constrained by sparse mutation burdens and analytic pipelines reliant on matched transcriptomes. Currently, gene-centric analysis prevails, but overlooks the complex, multigene and pathway perturbations shaping tumor biology. We introduce RIPPLET, a DNA-only framework converting somatic variants i...

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Literature Corpus work: 19656bee-d13e-5999-9b68-92d59a078599
DOI: 10.1101/2025.09.17.676675

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