Article
Systematic analysis of somatic mutations impacting gene expression in 12 tumour types.
Nature communications - 5 Oct 2015
Ding Jiarui, McConechy Melissa K, Horlings Hugo M, Ha Gavin, Chun Chan Fong, Funnell Tyler, Mullaly Sarah C, Reimand Jüri, Bashashati Ali, Bader Gary D, Huntsman David, Aparicio Samuel, Condon Anne, Shah Sohrab P
Abstract excerpt
We present a novel hierarchical Bayes statistical model, xseq, to systematically quantify the impact of somatic mutations on expression profiles. We establish the theoretical framework and robust inference characteristics of the method using computational benchmarking. We then use xseq to analyse thousands of tumour data sets available through The Cancer Genome Atlas, to systematically quantify somatic mutations...
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