Article

Somatically Mutated Genes Under Positive and Negative Selection Found by Transcriptome Sequence Analysis Include Oncogene and Tumor Suppressor Candidates

2018-08-21

Abstract excerpt

<h4>Introduction</h4> Oncogenic somatic mutations confer proliferative advantage and undergo positive clonal selection. We developed software and applied new analytical approaches to identify: (1) somatic mutations in diverse tissues, (2) somatically mutated genes under positive and negative selection, (3) post-transcriptional modifications in the mitochondrial transcriptome, and (4) inherited germline alleles pr...

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Literature Corpus work: e47370ef-4d29-5274-960d-315718927fc7
DOI: 10.1101/396739

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