Article

ButterflyVI: enabling high-throughput variant interpretation and biomarker discovery with functional genomics

2026-01-22

Abstract excerpt

Characterizing the functional and therapeutic relevance of cancer mutations is a primary goal and a major challenge in precision oncology. Whereas predictive approaches exist, they often lack functional validation, which cannot scale to large numbers of cancer-associated variants. Here, we integrated statistical learning with experimental evidence from high-throughput functional screenings to annotate >20000 uniqu...

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Literature Corpus work: 874d4746-9ae6-528a-8dff-acc7039b721c
DOI: 10.64898/2026.01.20.700339

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