Mutation impact on mRNA versus protein expression across human cancers.

Abstract excerpt

BACKGROUND: Cancer mutations are often assumed to alter proteins, thus promoting tumorigenesis. However, how mutations affect protein expression-in addition to gene expression-has rarely been systematically investigated. This is significant as mRNA and protein levels frequently show only moderate correlation, driven by factors such as translation efficiency and protein degradation. Proteogenomic datasets from...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Expression Regulation, Neoplastic
• Share to MSH3 gene
• Share to NF1 gene