Inter-Organelle Crosstalk in Oxidative Distress: A Unified TRPM2-NOX2 Mediated Vicious Cycle Involving Ca²⁺, Zn²⁺, and ROS Amplification

Abstract excerpt

Reactive oxygen species (ROS) are critical signalling molecules, but their overproduction leads to oxidative stress (OS), a common denominator in the pathogenesis of numerous non-communicable diseases (NCDs) and aging. General antioxidant therapies have largely been unsuccessful, highlighting the need for a deeper understanding of ROS amplification mechanisms to develop targeted interventions. This review proposes...

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• Adipose Tissue and Metabolism
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• Cancer, Hypoxia, and Metabolism
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• Mitochondrial Function and Pathology

Identifiers and source

Literature Corpus work

f35855f9-44cf-52ce-80f4-5d34a1665c02

DOI

10.20944/preprints202505.1560.v1