Article

<i>In vivo</i> suppression of polyglutamine aggregation via co-condensation of the molecular chaperone DNAJB6

2022-08-23

Abstract excerpt

Amyloidogenic protein aggregation is a hallmark of several human neurodegenerative conditions, including Alzheimer’s, Parkinson’s, and Huntington’s disease (HD). Mutations and/or environmental stresses trigger conformational transition of specific proteins to amyloids, conferring them with gain of toxic function, which eventually leads to cell death in distinct brain areas. Cumulative data indicate that modulation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c08325fc-eea7-5bf7-ab73-eab4e8869ae2
DOI: 10.1101/2022.08.23.504914

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In vivo</i> suppression of polyglutamine aggregation via co-condensation of the molecular chaperone DNAJB6DOI 10.1101/2022.08.23.504914Read

Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G.Semantic proximity Read

A multiplex platform to identify mechanisms and modulators of proteotoxicity in neurodegenerationSemantic proximity Read

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicitySemantic proximity Read

BAG2 Condensates Couple Proteostasis to CD8 <sup>+</sup> T Cell SurveillanceSemantic proximity Read

Tertiary structure and conformational dynamics of the anti-amyloidogenic chaperone DNAJB6b at atomistic resolutionSemantic proximity Read

Neurotoxic protein oligomerisation associated with polyglutamine diseases.Semantic proximity Read

Nuclear-injuries by aberrant dynein-forces defeat proteostatic purposes of Lewy Body InclusionsSemantic proximity Read

Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleationSemantic proximity Read

Hsp40s play complementary roles in the prevention of tau amyloid formation.Semantic proximity Read

The Hsp40 co-chaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregationSemantic proximity Read

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.Semantic proximity Read

Multi-Step Hsp70 Recruitment by Class B J-Domain Proteins Drives Efficient Protein DisaggregationSemantic proximity Read