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Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A β-Lactamases from the Antibiotic-Resistant Bacteria

1998-09-01

Abstract excerpt

Bacteria resistant to antibiotics are being selected in a relatively short time, and cases of infections resistant to treatment by all known antibiotics are being identified at alarming rates. The primary mechanism for resistance to β-lactam antibiotics is the catalytic function of β-lactamases. However, imipenem (a β-lactam) resists the action of most β-lactamases and is virtually the last effective agent against...

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Literature Corpus work: c05b9284-9000-583d-ae67-4fb6b3785f02
DOI: 10.1021/ja9818001

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