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Article

Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity.

The Journal of biological chemistry - 10 Aug 2018

Cheng Zishuo, Thomas Pei W, Ju Lincheng, Bergstrom Alexander, Mason Kelly, Clayton Delaney, Miller Callie, Bethel Christopher R, VanPelt Jamie, Tierney David L, Page Richard C, Bonomo Robert A, Fast Walter, Crowder Michael W

Abstract excerpt

Infections by carbapenem-resistant Enterobacteriaceae are difficult to manage owing to broad antibiotic resistance profiles and because of the inability of clinically used β-lactamase inhibitors to counter the activity of metallo-β-lactamases often harbored by these pathogens. Of particular importance is New Delhi metallo-β-lactamase (NDM), which requires a di-nuclear zinc ion cluster for catalytic activity....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29909397
DOI: 10.1074/jbc.RA118.003835
PMCID: PMC6093243

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