Article

Hydrogen-bonding changes cause differences in imipenem breakdown activity in OXA-48 variants

2026-01-22

Abstract excerpt

The β -lactamase OXA-48 efficiently hydrolyses carbapenem antibiotics, especially imipenem. Carbapenem resistance is a rising clinical concern, and is frequently associated with OXA-48 and its variants. OXA-48 variants carrying different mutations in the β 5 - β 6 loop differ in hydrolytic activity towards imipenem. OXA-517 has a higher K M , but similar k cat for imipenem hydrolysis, compared to OXA-48, wher...

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Literature Corpus work: 8e4166e5-d362-5f47-b44a-622fa24d647f
DOI: 10.64898/2026.01.20.700306

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