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Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysis

20 Mar 2007

Abstract excerpt

Combating bacterial resistance to beta-lactams, the most widely used antibiotics, is an emergent and clinically important challenge. OXA-24 is a class D beta-lactamase isolated from a multiresistant epidemic clinical strain of Acinetobacter baumannii. We have investigated how OXA-24 specifically hydrolyzes the last resort carbapenem antibiotic, and we have determined the crystal structure of OXA-24 at a...

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PMID: 17374723
DOI: 10.1073/pnas.0607557104

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