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Article

Hydrogen-Bonding Changes Cause Differences in Imipenem Breakdown Activity in OXA-48 Variants.

Journal of chemical information and modeling - 11 May 2026

Wang Daojiong, Mulholland Adrian J, Spencer James, van der Kamp Marc W

Abstract excerpt

The β-lactamase OXA-48 efficiently hydrolyzes carbapenem antibiotics, especially imipenem. Carbapenem resistance is a rising clinical concern and is frequently associated with OXA-48 and its variants. OXA-48 variants carrying different mutations in the β5-β6 loop differ in hydrolytic activity toward imipenem. OXA-517 has a higher KM, but a similar kcat for imipenem hydrolysis, compared to that of OXA-48, whereas...

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Identifiers

PMID: 42018524
DOI: 10.1021/acs.jcim.6c00223
PMCID: PMC13169374

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