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The Human LRRK2-R1441G Mutation Drives Age-Dependent Oxidative Stress and Mitochondrial Dysfunction in Dopaminergic Neurons

2025-12-03

Abstract excerpt

<title>Abstract</title> <p>Background Mitochondrial dysfunction and oxidative stress are central to the pathogenesis of Parkinson’s disease (PD), particularly affecting substantia nigra pars compacta (SNc) dopamine (DA) neurons. Here, we investigate how the R1441G mutation in leucine-rich repeat kinase 2 (LRRK2), a key genetic contributor to familial and sporadic PD, impacts mitochondrial function in midbrain DA...

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Literature Corpus work: 015a4aae-f032-5ef8-bd89-47d8db47fa16
DOI: 10.21203/rs.3.rs-8177400/v1

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