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Article

SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemia

2022-06-03

Abstract excerpt

<h4>Background: </h4> We screened out several hypermethylated solute carrier (SLC) family genes in acute myeloid leukemia (AML) by reduced representation bisulfite sequencing (RRBS). SLC22A3 encodes an organic cation transport protein, which is critical for drug transportation and cellular detoxification. SLC22A3 is significantly downregulated and associated with tumor progression and worse prognosis in a variety...

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Literature Corpus work
42966f23-a5dd-5592-971e-8cab2ebdb32a
DOI
10.21203/rs.3.rs-1715112/v1
Open publication

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SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemiaDOI 10.21203/rs.3.rs-1715112/v1
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