Article

BMP Signaling Downstream of the Highwire E3 Ligase Sensitizes Nociceptors

2018-01-22

Abstract excerpt

A comprehensive understanding of the molecular machinery important for nociception is essential to improving the treatment of pain. Here, we show that the BMP signaling pathway regulates nociception downstream of the E3 ubiquitin ligase highwire ( hiw ). Hiw loss of function in nociceptors caused antagonistic and pleiotropic phenotypes with simultaneous insensitivity to noxious heat but sensitized responses to...

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Literature Corpus work: c0221bea-2efb-552c-a257-82c13e19a0ee
DOI: 10.1101/251991

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