Article
Genetic control of the segregation of pain-related sensory neurons innervating the cutaneous versus deep tissues.
Cell reports - 12 Dec 2013
Yang Fu-Chia, Tan Taralyn, Huang Tianwen, Christianson Julie, Samad Omar A, Liu Yang, Roberson David, Davis Brian M, Ma Qiufu
Abstract excerpt
Mammalian pain-related sensory neurons are derived from TrkA lineage neurons located in the dorsal root ganglion. These neurons project to peripheral targets throughout the body, which can be divided into superficial and deep tissues. Here, we find that the transcription factor Runx1 is required for the development of many epidermis-projecting TrkA lineage neurons. Accordingly, knockout of Runx1 leads to the...
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