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Article

Highwire regulates presynaptic BMP signaling essential for synaptic growth.

Neuron - 25 Mar 2004

McCabe Brian D, Hom Sabrina, Aberle Hermann, Fetter Richard D, Marques Guillermo, Haerry Theodore E, Wan Hong, O'Connor Michael B, Goodman Corey S, Haghighi A Pejmun

Abstract excerpt

Highwire (Hiw), a putative RING finger E3 ubiquitin ligase, negatively regulates synaptic growth at the neuromuscular junction (NMJ) in Drosophila. hiw mutants have dramatically larger synaptic size and increased numbers of synaptic boutons. Here we show that Hiw binds to the Smad protein Medea (Med). Med is part of a presynaptic bone morphogenetic protein (BMP) signaling cascade consisting of three receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15046722
DOI: 10.1016/s0896-6273(04)00073-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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