Article
Duox mediates ultraviolet injury-induced nociceptive sensitization in Drosophila larvae.
Molecular brain - 14 Mar 2018
Jang Wijeong, Baek Minwoo, Han Yeon Soo, Kim Changsoo
Abstract excerpt
BACKGROUND: Nociceptive sensitization is an increase in pain perception in response to stimulus. Following brief irradiation of Drosophila larvae with UV, nociceptive sensitization occurs in class IV multiple dendritic (mdIV) neurons, which are polymodal sensory nociceptors. Diverse signaling pathways have been identified that mediate nociceptive sensitization in mdIV neurons, including TNF, Hedgehog, BMP, and...
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